Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04JCN
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| Former ID |
DAP000069
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| Drug Name |
Pergolide
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| Synonyms |
Pergolida; Pergolidum; Permax; Pergolida [INN-Spanish]; Pergolide (INN); Pergolide [INN:BAN]; Pergolidum [INN-Latin]; Permax (TN); LY-127,809; (6aR,9R,10aR)-9-(Methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline; (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline; (8beta)-8-[(methylthio)methyl]-6-propylergoline
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Antiparkinson Agents
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| Company |
Valeant Pharmaceuticals
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| Structure |
|
Download2D MOL |
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| Formula |
C19H26N2S
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| InChI |
InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
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| InChIKey |
YEHCICAEULNIGD-MZMPZRCHSA-N
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| CAS Number |
CAS 66104-22-1
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9629, 7980280, 8180418, 11335617, 11360856, 11364541, 11367103, 11369665, 11372755, 11374547, 11377827, 11461828, 11466323, 11467443, 11485835, 11486185, 11489786, 11491403, 11492650, 11495461, 14825868, 14874447, 22390536, 24263009, 26754330, 26754331, 34712767, 46507604, 47588942, 47588943, 47662223, 47736415, 47736416, 47810696, 47810697, 47885355, 48110404, 48259176, 48416397, 48484161, 49698421, 49965528, 50109822, 50586184, 57288804, 57313147, 85788351, 85789354, 90341767, 92308734
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| SuperDrug ATC ID |
N04BC02
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| SuperDrug CAS ID |
cas=066104221
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| Target and Pathway | |||||
| Target(s) | Dopamine D1 receptor | Target Info | Modulator | [556264] | |
| D(2) dopamine receptor | Target Info | Modulator | [556264] | ||
| PANTHER Pathway | Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| PathWhiz Pathway | Dopamine Activation of Neurological Reward System | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| Ref 468029 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 48). | ||||
| Ref 536285 | Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. | ||||
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