Drug General Information
Drug ID	D04JMK
Former ID	DNC012070
Drug Name	Derivative of methotrexate
Indication	Discovery agent		Investigative	[533568]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Dihydrofolate reductase	Target Info	Inhibitor	[533568]
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
References
Ref 533568	J Med Chem. 1982 Feb;25(2):182-7.Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.
Ref 533568	J Med Chem. 1982 Feb;25(2):182-7.Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.

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