Drug General Information
Drug ID	D04JUJ
Former ID	DNC003906
Drug Name	1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551342]
Structure		Download 2D MOL 3D MOL
Formula	C10H13NO2
Canonical SMILES	CC1C2=CC(=C(C=C2CCN1)O)O
InChI	1S/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3
InChIKey	IBRKLUSXDYATLG-UHFFFAOYSA-N
PubChem Compound ID	54456
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Inhibitor	[551342]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 551342	D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis, Bioorg. Med. Chem. Lett. 7(9):1207-1212 (1997).
Ref 551342	D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis, Bioorg. Med. Chem. Lett. 7(9):1207-1212 (1997).

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