TTD | Drug: D04JZJ

Drug General Information
Drug ID	D04JZJ
Former ID	DNC004824
Drug Name	3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527368]
Structure		Download 2D MOL 3D MOL
Formula	C22H23NO2
Canonical SMILES	C1CN(CCC1CC2=CC=CC=C2)CC3=COC4=CC=CC=C4C3=O
InChI	1S/C22H23NO2/c24-22-19(16-25-21-9-5-4-8-20(21)22)15-23-12-10-18(11-13-23)14-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2
InChIKey	WZWRAAKVOATXPL-UHFFFAOYSA-N
PubChem Compound ID	2838196
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[527368]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527368	J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Ref 527368	J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.

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Drug Information