Drug General Information
Drug ID	D04JZP
Former ID	DIB015769
Drug Name	Mazapertine succinate
Synonyms	RWJ-37796
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Phase 2	[534644]
Company	RW Johnson Pharmaceutical Research Institute
Structure		Download 2D MOL 3D MOL
Formula	C30H41N3O6
Canonical SMILES	C(=O)(N1CCCCC1)c1cc(CN2CCN(c3c(OC(C)C)cccc3)CC2)ccc1.C(<br />=O)(CCC(=O)O)O
PubChem Compound ID	60819
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Modulator
	D(2) dopamine receptor	Target Info	Modulator
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04015:Rap1 signaling pathway
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 534644	Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem. 1998 Jun 4;41(12):1997-2009.

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