Drug Information

Drug General Information
Drug ID
D04KQF
Former ID
DNC001476
Drug Name
Tubacin
Drug Type
Small molecular drug
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Investigative [542395]
Company
Broad Institute
Structure
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2D MOL

3D MOL
Formula
C41H43N3O7S
InChI
InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
InChIKey
BHUZLJOUHMBZQY-YXQOSMAKSA-N
PubChem Compound ID
6675804
PubChem Substance ID
11301280, 15064041, 17189945, 43295412, 49846263, 74481532, 87226487, 103386582, 114660292, 134222778, 141769758, 162207355, 163121428, 172650171, 174007120, 177748466, 178103946, 188919873, 198964009, 230639396, 241376440, 245136023, 252157262
Target and Pathway
Target(s) Histone deacetylase 6 Target Info Inhibitor [536272], [537114]
KEGG Pathway Alcoholism
Viral carcinogenesis
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary cilium
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell Cycle
References
Ref 542395(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7374).
Ref 536272Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84.
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.

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