TTD | Drug: D04LSH

Drug General Information
Drug ID	D04LSH
Former ID	DND000087
Drug Name	SAR101099
Indication	Diabetic nephropathy [ICD9: 250.4; ICD10:E11.21]		Discontinued in Phase 1	[549207]
Company	Sanofi
Target and Pathway
Target(s)	Urotensin II receptor	Target Info	Antagonist	[543795]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 549207	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033702)
Ref 543795	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 365).

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Drug Information