Drug General Information
Drug ID
D04LWO
Former ID
DIB010579
Drug Name
Hydromorphone prodrug
Synonyms
PF-03 program; PF-329; Hydromorphone prodrug (Bio-MD/MPAR/oral, pain), PharmacoFore; Hydromorphone prodrug (Bio-MD, tamper/abuse-resistant, pain), PharmacoFore; Hydromorphone prodrug (Bio-MD/MPAR/oral/extended-release, pain); Hydromorphone prodrug (Bio-MD/MPAR/oral/extended-release, pain), PharmacoFore; Hydromorphone prodrug (tamper/abuse-resistant, Bio-MD/extended-release, Pain), PharmacoFore
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 1 [549269]
Company
PharmacoFore Inc
Structure
Download
2D MOL

3D MOL

Formula
C17H19NO3
Canonical SMILES
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4
InChI
1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
InChIKey
WVLOADHCBXTIJK-YNHQPCIGSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Inhibitor [551690]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 549269Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034401)
Ref 551690Clinical pipeline report, company report or official report of signaturerx.

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