Drug Information

Drug General Information
Drug ID
D04LWT
Former ID
DNCL002018
Drug Name
GSK1440115
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 1 [523601]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C30H29Cl2N3O6
Canonical SMILES
CN(C(CN1CCOCC1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)O)C(=O)CN<br />4C(=O)COC5=CC(=C(C=C54)Cl)Cl
InChI
1S/C30H29Cl2N3O6/c1-33(28(36)17-35-25-14-23(31)24(32)15-27(25)41-18-29(35)37)26(16-34-10-12-40-13-11-34)21-6-2-19(3-7-21)20-4-8-22(9-5-20)30(38)39/h2-9,14-15,26H,10-13,16-18H2,1H3,(H,38,39)/t26-/m0/s1
InChIKey
YNBJTYUXPHTSFF-SANMLTNESA-N
PubChem Compound ID
24760693
PubChem Substance ID
49664526, 56174159, 135267385, 137202777, 141791363, 198935745, 229019631, 245625812
Target and Pathway
Target(s) Urotensin II receptor Target Info Antagonist [544303]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523601ClinicalTrials.gov (NCT01424280) Single Dose Study of GSK1440115 in Patients With Asthma. U.S. National Institutes of Health.
Ref 544303Effects of Urotensin II Receptor Antagonist, GSK1440115, in Asthma. Front Pharmacol. 2013; 4: 54.

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