Drug Information

Drug General Information
Drug ID
D04MKB
Former ID
DNC011215
Drug Name
ST-1025
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531116]
Structure
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2D MOL

3D MOL
Formula
C23H26N2OS
Canonical SMILES
C1CCN(CC1)CCCOC2=NC(=C(S2)C3=CC=CC=C3)C4=CC=CC=C4
InChI
1S/C23H26N2OS/c1-4-11-19(12-5-1)21-22(20-13-6-2-7-14-20)27-23(24-21)26-18-10-17-25-15-8-3-9-16-25/h1-2,4-7,11-14H,3,8-10,15-18H2
InChIKey
QRGQBMVHLMCOKC-UHFFFAOYSA-N
PubChem Compound ID
46898078
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [531116]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 531116Bioorg Med Chem Lett. 2010 Oct 1;20(19):5883-6. Epub 2010 Aug 1.Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles.
Ref 531116Bioorg Med Chem Lett. 2010 Oct 1;20(19):5883-6. Epub 2010 Aug 1.Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles.

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