Drug Information

Drug General Information
Drug ID
D04MKJ
Former ID
DCL000954
Drug Name
Renzapride
Synonyms
Renzaprida; Renzapridum; Renzapride [INN]; Renzaprida [INN-Spanish]; Renzapridum [INN-Latin]; ((-)-endo)-4-Amino-5-chloro-2-methoxy-N-(1-azabicyclo(3.3.1)non-4-yl)benzamide; 4-amino-N-[(4S,5S)-1-azabicyclo[3.3.1]nonan-4-yl]-5-chloro-2-methoxybenzamide
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Phase 3 [536224], [539568]
Company
Alizyme
Structure
Download
2D MOL

3D MOL
Formula
C16H22ClN3O2
InChI
InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-14-4-6-20-5-2-3-10(14)9-20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
InChIKey
GZSKEXSLDPEFPT-HZMBPMFUSA-N
CAS Number
CAS 112727-80-7
PubChem Compound ID
3086547
PubChem Substance ID
9472200, 14752856, 36416309, 50070408, 50071049, 57356003, 80768060, 111695088, 135236244, 135367542, 135650894, 152049248, 198959042, 226973439
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Modulator
5-HT 3 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
Ref 539568(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 244).

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