Drug Information

Drug General Information
Drug ID
D04OKJ
Former ID
DCL000334
Drug Name
Garenoxacin
Synonyms
T 3811; T-3811; T-3811MEa; BMS 284756 (*Mesylate salt*); BMS-284756 (*Mesylate salt*);1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid
Drug Type
Small molecular drug
Indication Endocarditis [ICD9: 421; ICD10:I33] Terminated [536094]
Company
Toyama Chemical
Structure
Download
2D MOL

3D MOL
Formula
C23H20F2N2O4
Canonical SMILES
CC1C2=C(CN1)C=C(C=C2)C3=C(C4=C(C=C3)C(=O)C(=CN4C5CC5)C(<br />=O)O)OC(F)F
InChI
1S/C23H20F2N2O4/c1-11-15-5-2-12(8-13(15)9-26-11)16-6-7-17-19(21(16)31-23(24)25)27(14-3-4-14)10-18(20(17)28)22(29)30/h2,5-8,10-11,14,23,26H,3-4,9H2,1H3,(H,29,30)/t11-/m1/s1
InChIKey
NJDRXTDGYFKORP-LLVKDONJSA-N
CAS Number
CAS 91421-42-0
PubChem Compound ID
124093
PubChem Substance ID
629682, 10240978, 14782848, 14929713, 29304220, 50126319, 50198260, 57340754, 103500851, 104420046, 126681318, 126731325, 128709999, 134222367, 134338988, 135078604, 136367936, 136376435, 137211650, 142246907, 143496458, 144116000, 152059700, 152234926, 160821171, 162185570, 162263711, 162809937, 164023430, 164841947, 174476558, 174528172, 179150179, 198974823, 204431665, 223554218, 223663074, 223763968, 228243331, 249823130, 250203584, 251971067, 252058460, 252434392
Target and Pathway
Target(s) DNA topoisomerase II Target Info Inhibitor [535226]
References
Ref 536094Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
Ref 535226The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues. J Antimicrob Chemother. 2001 Aug;48(2):195-201.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.