Drug Information

Drug General Information
Drug ID
D04QLR
Former ID
DAP000509
Drug Name
Dyclonine
Synonyms
Diclonia; Diclonina; Dyclocaine; Dyclocainum; Dyclonin; Dycloninum; Dyclothane; Tanaclone; Diclonina [INN-Spanish]; Dyclonine (INN); Dyclonine [INN:BAN]; Dycloninum [INN-Latin]; 1-(4-Butoxy-phenyl)-3-piperidin-1-yl-propan-1-one; 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone; 1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one; 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one; 1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-(9CI); 2-(1-piperidyl)ethyl p-butoxyphenyl ketone; 3-Piperidino-4'-butoxypropiophenone; 4'-Butoxy-3-piperidinopropiophenone; 4-butoxy-beta-piperidinopropiophenone; 4-n-butoxy-beta-(1-piperidyl)propiophenone
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538425], [542183], [551871]
Therapeutic Class
Anesthetics
Company
Astrazeneca Lp
Structure
Download
2D MOL

3D MOL
Formula
C18H27NO2
InChI
InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3
InChIKey
BZEWSEKUUPWQDQ-UHFFFAOYSA-N
CAS Number
CAS 586-60-7
PubChem Compound ID
3180
PubChem Substance ID
10083, 7726237, 7979140, 8152025, 10589257, 11112403, 11335807, 11361046, 11363910, 11366472, 11369034, 11371260, 11374276, 11377196, 11462018, 11466292, 11467412, 11484901, 11486063, 11488829, 11490226, 11492344, 11494830, 15270786, 25667259, 29222322, 46506697, 47216771, 47515313, 47736472, 47885405, 48035111, 48035112, 48110446, 49698861, 50026050, 50100427, 50713692, 57321651, 85789355, 92711541, 96024577, 99319105, 104302759, 105052237, 117720385, 123090168, 124596734, 124882339, 124882340
SuperDrug ATC ID
N01BX02; R02AD04
SuperDrug CAS ID
cas=000586607
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Blocker [538082]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 538425FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009925.
Ref 542183(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7173).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 538082Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.

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