Drug Information

Drug General Information
Drug ID
D04TCU
Former ID
DNC005863
Drug Name
CMI-977
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 2 [546341]
Structure
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2D MOL

3D MOL
Formula
C16H19FN2O4
Canonical SMILES
C1CC(OC1COC2=CC=C(C=C2)F)C#CCCN(C(=O)N)O
InChI
1S/C16H19FN2O4/c17-12-4-6-13(7-5-12)22-11-15-9-8-14(23-15)3-1-2-10-19(21)16(18)20/h4-7,14-15,21H,2,8-11H2,(H2,18,20)/t14-,15+/m1/s1
InChIKey
YANONWCPCKIWEC-CABCVRRESA-N
PubChem Compound ID
9905233
Target and Pathway
Target(s) mRNA of human 5-lipoxygenase Target Info Inhibitor [527799]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 546341Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007577)
Ref 527799J Med Chem. 2005 Oct 20;48(21):6523-43.Designed multiple ligands. An emerging drug discovery paradigm.

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