Drug Information

Drug General Information
Drug ID
D04TLI
Former ID
DIB019364
Drug Name
compound 23
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528928]
Structure
Download
2D MOL
Formula
C17H17N5O3S
InChI
InChI=1S/C17H17N5O3S/c1-11-5-6-13(23)10-15(11)21-16-7-8-19-17(22-16)20-12-3-2-4-14(9-12)26(18,24)25/h2-10,23H,1H3,(H2,18,24,25)(H2,19,20,21,22)
InChIKey
LKLIRPMEYRVLFV-UHFFFAOYSA-N
PubChem Compound ID
23657507
PubChem Substance ID
46529899, 56035367, 56464603, 103551394, 180398604, 249565826
Target and Pathway
Target(s) TXK tyrosine kinase Target Info Inhibitor [528928]
Tyrosine-protein kinase SYK Target Info Inhibitor [528928]
Lyn tyrosine kinase Target Info Inhibitor [528928]
Lck tyrosine kinase Target Info Inhibitor [528928]
KEGG Pathway NF-kappa B signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
Epstein-Barr virus infection
Viral carcinogenesishsa04062:Chemokine signaling pathway
Long-term depression
Epithelial cell signaling in Helicobacter pylori infection
Viral carcinogenesishsa04064:NF-kappa B signaling pathway
T cell receptor signaling pathway
HTLV-I infection
Primary immunodeficiency
NetPath Pathway IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway B cell activationP00010:B cell activation
Parkinson disease
CCKR signaling map STP00049:Parkinson disease
T cell activation
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
GMCSF-mediated signaling events
Atypical NF-kappaB pathway
Osteopontin-mediated events
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
IL2-mediated signaling events
Class I PI3K signaling events
Alpha-synuclein signalingfcer1pathway:Fc-epsilon receptor I signaling in mast cells
LPA receptor mediated events
Glypican 1 network
Signaling events mediated by PTP1B
Regulation of p38-alpha and p38-beta
CXCR4-mediated signaling events
IL5-mediated signaling events
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL8- and CXCR2-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
IL8- and CXCR1-mediated signaling events
Ephrin B reverse signaling
Alpha-synuclein signalingnfkappabatypicalpathway:Atypical NF-kappaB pathway
TCR signaling in na&#xef
IL12-mediated signaling events
TCR signaling in na&#xef
SHP2 signaling
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Alpha-synuclein signaling
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Integrin alphaIIb beta3 signaling
Interleukin-2 signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-114604:GPVI-mediated activation cascade
Regulation of KIT signaling
Cell surface interactions at the vascular wall
PECAM1 interactions
EPH-Ephrin signaling
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
CD209 (DC-SIGN) signaling
Platelet Adhesion to exposed collagen
Growth hormone receptor signaling
PIP3 activates AKT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
PD-1 signaling
WikiPathways IL-2 Signaling Pathway
IL-3 Signaling Pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Interleukin-2 signaling
Fcgamma receptor (FCGR) dependent phagocytosis
DAP12 interactions
B Cell Receptor Signaling Pathway
RANKL/RANK Signaling Pathway
Integrin alphaIIb beta3 signaling
GPVI-mediated activation cascade
Regulation of toll-like receptor signaling pathway
IL-5 Signaling PathwayWP304:Kit receptor signaling pathway
Signaling by SCF-KIT
Growth hormone receptor signaling
TSLP Signaling Pathway
Platelet Adhesion to exposed collagen
Costimulation by the CD28 family
Cell surface interactions at the vascular wall
IL-5 Signaling PathwayWP61:Notch Signaling Pathway
Interferon type I signaling pathways
Inflammatory Response Pathway
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
TCR signaling
References
Ref 528928Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. Epub 2007 Apr 13.N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Ref 528928Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. Epub 2007 Apr 13.N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.

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