Drug Information

Drug General Information
Drug ID
D04TTP
Former ID
DNC008127
Drug Name
5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529305]
Structure
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2D MOL

3D MOL
Formula
C11H6Br2N2O
Canonical SMILES
C1=CN=CC2=C1C3=C(C(=C(C=C3N2)Br)O)Br
InChI
1S/C11H6Br2N2O/c12-6-3-7-9(10(13)11(6)16)5-1-2-14-4-8(5)15-7/h1-4,15-16H
InChIKey
UNIUKKWPGRGSRQ-UHFFFAOYSA-N
PubChem Compound ID
127993
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [529305]
Adenosine A2a receptor Target Info Inhibitor [529305]
Adenosine A1 receptor Target Info Inhibitor [529305]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholismhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
G alpha (s) signalling events
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
References
Ref 529305Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. Epub 2008 Jan 30.Synthesis of eudistomin D analogues and its effects on adenosine receptors.
Ref 529305Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. Epub 2008 Jan 30.Synthesis of eudistomin D analogues and its effects on adenosine receptors.

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