Drug Information

Drug General Information
Drug ID
D04ULU
Former ID
DIB020037
Drug Name
icilin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539558]
Structure
Download
2D MOL
Formula
C16H13N3O4
InChI
InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChIKey
RCEFMOGVOYEGJN-UHFFFAOYSA-N
PubChem Compound ID
161930
PubChem Substance ID
1240210, 3621329, 5192448, 10254648, 11111340, 11114126, 14752197, 17404989, 24277906, 24787011, 26119358, 46236694, 48094538, 48169372, 50036852, 50104889, 50104890, 53777532, 56463310, 57309620, 57349717, 57778978, 76773620, 85231095, 85787617, 89309934, 90341669, 92303991, 103123169, 103123170, 103563389, 104098764, 104917575, 113448265, 117621557, 121361218, 124749705, 124880477, 124880478, 125134295, 125334116, 129108203, 135117301, 135335475, 135650372, 135698361, 137101079, 137290080, 143156165, 162023115
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [526579]
TRPM8 protein Target Info Activator [530184]
KEGG Pathway Inflammatory mediator regulation of TRP channelshsa04750:Inflammatory mediator regulation of TRP channels
Reactome TRP channelsR-HSA-3295583:TRP channels
References
Ref 539558(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2429).
Ref 526579ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29.
Ref 530184Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741.

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