Drug General Information
Drug ID	D04UNO
Former ID	DIB015997
Drug Name	KUL-7211
Indication	Neurogenic bladder dysfunction [ICD10:N31.9]		Phase 1	[547180]
Company	Kissei Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(COc1ccc(cc1)CCN[C@H]([C@@H](c1ccc(cc1)O)O)C)O
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Modulator	[526702]
	Beta-3 adrenergic receptor	Target Info	Modulator	[526702]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretionhsa04020:Calcium signaling pathway
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
References
Ref 547180	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013676)
Ref 526702	Pharmacological profile of KUL-7211, a selective beta-adrenoceptor agonist, in isolated ureteral smooth muscle. J Pharmacol Sci. 2003 Aug;92(4):411-9.

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