Drug Information

Drug General Information
Drug ID
D04UVZ
Former ID
DNC011457
Drug Name
CGP-27492
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538663]
Formula
C3H9NO2P+
InChI
InChI=1S/C3H8NO2P/c4-2-1-3-7(5)6/h1-4H2/p+1
InChIKey
MQIWYGZSHIXQIU-UHFFFAOYSA-O
PubChem Compound ID
6335948
PubChem Substance ID
7978462, 15486542, 42980669, 46165014, 47880150, 48105251, 50070443, 50071087, 53786181, 57366201, 75591719, 87692409, 103334995, 114466071, 129952052, 132620419, 134348662, 135075891, 135649732, 137008677, 142796839, 163139645, 171579546, 178102039, 188919958, 223653391, 224931303, 226676850
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [533678]
Gamma-aminobutyric acid B receptor Target Info Inhibitor [551250]
Gamma-aminobutyric acid receptor Target Info Inhibitor [533678]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04024:cAMP signaling pathway
Estrogen signaling pathway
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-1296041:Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP501:GPCRs, Class C Metabotropic glutamate, pheromone
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 538663(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1081).
Ref 533678J Med Chem. 1995 Aug 18;38(17):3297-312.Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Ref 551250Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993).

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