Drug Information

Drug General Information
Drug ID
D04VPA
Former ID
DAP000510
Drug Name
Moricizine
Synonyms
Moracizin; Moracizina; Moracizine; Moracizinum; Moricizine [USAN]; G 214; EN-313; Moracizina [INN-Spanish]; Moracizine (INN); Moracizinum [INN-Latin]; Moricizine (USAN); Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate; Ethyl 10-(beta-N-morpholinylpropionyl)phenothiazine-2-carbamate; Ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate; Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester; Ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate; Ethyl {10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; Ethyl N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}carbamate; Ethyl (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)carbamate; Carbamic acid, (10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, ethyl ester
Drug Type
Small molecular drug
Indication Arrhythmia [ICD9: 427; ICD10:I47-I49] Approved [551871]
Heart arrhythmia [ICD10:I47-I49] Withdrawn from market [538532], [542261], [551871]
Therapeutic Class
Antiarrhythmic Agents
Company
Shire Development Inc
Structure
Download
2D MOL

3D MOL
Formula
C22H25N3O4S
InChI
InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)
InChIKey
FUBVWMNBEHXPSU-UHFFFAOYSA-N
CAS Number
CAS 31883-05-3
PubChem Compound ID
34633
PubChem Substance ID
9945, 4026447, 7388142, 7980016, 8173724, 11112721, 11137751, 11467079, 11468199, 11486667, 11500554, 14782938, 25680943, 34676267, 46509072, 47206804, 47377252, 47897104, 47971880, 48271403, 48271404, 48346667, 48416294, 49699387, 49900350, 50086819, 50105209, 50236557, 56459387, 57311701, 58007385, 61030619, 85788904, 92289659, 93166657, 103293612, 104222092, 104319116, 106034887, 117439362, 117439364, 117579671, 124513927, 124882570, 124882571, 124882572, 125163413, 125824582, 127899847, 134337803
SuperDrug ATC ID
C01BG01
SuperDrug CAS ID
cas=031883053
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Blocker [537980]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 538532FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019753.
Ref 542261(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7244).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537980From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.

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