Drug Information

Drug General Information
Drug ID
D04YJU
Former ID
DNC003854
Drug Name
L-755507
Drug Type
Small molecular drug
Indication Discovery agent Terminated [540554], [546489]
Structure
Download
2D MOL

3D MOL
Formula
C30H40N4O6S
InChI
InChI=1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1
InChIKey
NYYJKMXNVNFOFQ-MHZLTWQESA-N
PubChem Compound ID
9829836
PubChem Substance ID
14789009, 14789010, 24131216, 26753228, 44927958, 76787435, 91746344, 103174873, 103964074, 128774706, 134341059, 135698577, 142401324, 142510250, 178100760, 231023254, 241375816, 252156350
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Inhibitor [526033]
Cruzipain Target Info Inhibitor [530512]
Beta-2 adrenergic receptor Target Info Inhibitor [526033]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 540554(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3931).
Ref 546489Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008526)
Ref 526033J Med Chem. 2001 Apr 26;44(9):1456-66.(4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists.
Ref 530512J Med Chem. 2010 Jan 14;53(1):37-51.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

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