Drug Information

Drug General Information
Drug ID
D05BQK
Former ID
DAP000668
Drug Name
Butalbital
Synonyms
Alisobumal; Alisobumalum; Allylbarbital; Allylbarbitone; Allylisobutylbarbital; Allylisobutylbarbiturate; Butalbarbital;Butalbitale; Butalbitalum; Itobarbital; Profundal; Sandoptal; Tetrallobarbital; Butalbitale [DCIT]; Axocet (TN); Axotal (TN); Bucet (TN); Bupap (TN); Butalbital [USAN:INN]; Butalbitalum [INN-Latin]; Cephadyn (TN); Dolgic (TN); Esgic (TN); Fioricet (TN); Fiorinal (TN); Fiormor (TN); Fiortal (TN); Fortabs (TN); IBS-L0126512; Iso-butylallylbarbituric acid; Laniroif (TN); Phrenilin (TN); Phrenilin Forte (TN); Sandoptal (TN); Sedapap (TN); Butalbital (USP/INN); Esgic-Plus (TN); 5-(2-methylpropyl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-(2-methylpropyl)-5-prop-2-en-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione; 5-Allyl-5-(2'-methyl-n-propyl) barbituric acid; 5-Allyl-5-(2-methylpropyl)barbituric acid; 5-Allyl-5-isobutyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Allyl-5-isobutyl-pyrimidine-2,4,6-trione; 5-Allyl-5-isobutylbarbituric acid
Drug Type
Small molecular drug
Indication Headache; Anxiety disorder [ICD9: 339, 784.0, 300, 311; ICD10:G43-G44, R51, F32, F40-F42] Approved [538316], [542145], [551871]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C11H16N2O3
InChI
InChI=1S/C11H16N2O3/c1-4-5-11(6-7(2)3)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)
InChIKey
UZVHFVZFNXBMQJ-UHFFFAOYSA-N
CAS Number
CAS 77-26-9
PubChem Compound ID
2481
PubChem Substance ID
5615386, 8150125, 8151657, 10535514, 11336145, 11361384, 11462356, 15018886, 17397336, 29221645, 46505876, 47589070, 48415671, 49873698, 50842826, 57321346, 71821583, 85308112, 99302058, 103166017, 104300716, 107945884, 117367338, 119511319, 126678058, 129444403, 134337957, 134972311, 135366363, 137131388, 137192290, 138744648, 152033795, 160963589, 164837438, 165745221, 175266092, 175611865, 177749228, 178103714, 179116585, 198993186, 223681171, 226458906, 241142339, 250049255
SuperDrug ATC ID
N05CA07
SuperDrug CAS ID
cas=000115446
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 538316FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076528.
Ref 542145(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7138).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.

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