Drug Information

Drug General Information
Drug ID
D05EPM
Former ID
DAP000512
Drug Name
Ethotoin
Synonyms
Accenon; Ethotoine; Ethotoinum; Etotoina; Peganone; Pegoanone; Abbott brand of ethotoin; Accenon (TN); Ethotoine [INN-French]; Ethotoinum [INN-Latin]; Etotoina [INN-Spanish]; Peganone (TN); Ethotoin [INN:BAN:JAN]; Ethotoin (JAN/USP/INN); (+-)-3-Ethyl-5-phenylhydantoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; 3-ethyl-5-phenylimidazolidine-2,4-dione
Drug Type
Small molecular drug
Indication Complex partial seizures [ICD9: 345.4; ICD10:G40.2] Approved [538439], [542194]
Therapeutic Class
Anticonvulsants
Company
Ovation Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C11H12N2O2
InChI
InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15)
InChIKey
SZQIFWWUIBRPBZ-UHFFFAOYSA-N
CAS Number
CAS 86-35-1
PubChem Compound ID
3292
PubChem Substance ID
10041, 5235098, 7847773, 7979201, 8152092, 10537073, 11466724, 11467844, 11486508, 15463341, 29222430, 46504521, 47314288, 47464128, 47834450, 47834451, 48134126, 48415979, 49699145, 49977230, 50124114, 50283352, 56459446, 56463534, 57321709, 92125817, 99437357, 103303661, 103913707, 104303083, 121363488, 124800256, 126407581, 134337805, 134970936, 137008519, 137260962, 140085433, 144076267, 144203934, 145259068, 160964097, 175611111, 177513114, 178103758, 178126524, 179116676, 221672900, 225144304, 226420792
SuperDrug ATC ID
N03AB01
SuperDrug CAS ID
cas=000086351
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Blocker [536316]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 538439FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010841.
Ref 542194(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7183).
Ref 536316How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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