Drug Information

Drug General Information
Drug ID
D05EPY
Former ID
DIB014347
Drug Name
L-693612
Synonyms
(-)-(2S,4S)-6-(3-Methoxypropyl)-4-(propylamino)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; 138301-71-0
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Investigative [531635], [533846]
Structure
Download
2D MOL

3D MOL
Formula
C14H24N2O5S3
Canonical SMILES
CCCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
InChI
1S/C14H24N2O5S3/c1-3-6-16-12-8-10(5-4-7-21-2)23(17,18)14-11(12)9-13(22-14)24(15,19)20/h9-10,12,16H,3-8H2,1-2H3,(H2,15,19,20)/t10-,12-/m0/s1
InChIKey
JNPHBSXNRNBLCV-JQWIXIFHSA-N
CAS Number
CAS 138301-71-0
PubChem Compound ID
67668482
PubChem Substance ID
135330239, 163641577, 198988420, 234188345
Target and Pathway
Target(s) Carbonic anhydrase I Target Info Modulator [531635], [533846]
KEGG Pathway Nitrogen metabolism
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 533846Dose-dependent pharmacokinetics of L-693,612, a carbonic anhydrase inhibitor, following oral administration in rats. Pharm Res. 1994 Mar;11(3):438-41.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 533846Dose-dependent pharmacokinetics of L-693,612, a carbonic anhydrase inhibitor, following oral administration in rats. Pharm Res. 1994 Mar;11(3):438-41.

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