Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05FFY
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| Former ID |
DNC004483
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| Drug Name |
1-(4-Cyanobenzyl)-5-methyl-1H-imidazole
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| Synonyms |
4-(5-Methyl-imidazol-1-ylmethyl)-benzonitrile
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| Indication | Discovery agent | Investigative | [530679] | ||
| Structure |
|
Download2D MOL |
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| Canonical SMILES |
CC1=CN=CN1CC2=CC=C(C=C2)C#N
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| InChI |
1S/C12H11N3/c1-10-7-14-9-15(10)8-12-4-2-11(6-13)3-5-12/h2-5,7,9H,8H2,1H3
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| InChIKey |
JYTDMONWVZXEMX-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Cytochrome P450 11B1, mitochondrial | Target Info | Inhibitor | [530679] | |
| Cytochrome P450 19 | Target Info | Inhibitor | [529291] | ||
| NetPath Pathway | FSH Signaling Pathway | ||||
| PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
| PathWhiz Pathway | SteroidogenesisPW000045:Androgen and Estrogen Metabolism | ||||
| WikiPathways | Metapathway biotransformation | ||||
| Oxidation by Cytochrome P450 | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Corticotropin-releasing hormoneWP702:Metapathway biotransformation | |||||
| Tryptophan metabolism | |||||
| Ovarian Infertility Genes | |||||
| FSH signaling pathway | |||||
| Integrated Breast Cancer Pathway | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| Ref 529291 | J Med Chem. 1991 Feb;34(2):725-36.Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. | ||||
| Ref 530679 | J Med Chem. 2010 Feb 25;53(4):1712-25.Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). | ||||
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