Drug Information

Drug General Information
Drug ID
D05FTY
Former ID
DIB009587
Drug Name
ES-1005
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [545147]
Company
Sankyo Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C50H69Cl2N7O6
Canonical SMILES
C(=O)(N[C@H]([C@H](CC(=O)N[C@H](C(=O)NCCCCC(N)CO)CC(C)C<br />)O)CC(C)C)[C@@H](NC(=O)C(Cc1c2c(ccc1)cccc2)Cc1c2c(ccc1)<br />cccc2)Cc1nc[nH]c1.Cl.Cl
CAS Number
CAS 112785-22-5
PubChem Compound ID
3082723
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [530272]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 545147Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002295)
Ref 530272The effect of the renin inhibitor ES-1005 on the expression of the kidney renin gene in sodium-depleted marmosets. J Hypertens. 1990 Dec;8(12):1143-6.

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