Drug Information

Drug General Information
Drug ID
D05GFT
Former ID
DNC006908
Drug Name
GNF-PF-3427
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528472]
Structure
Download
2D MOL
Formula
C24H24N4
Canonical SMILES
CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53
InChI
1S/C24H24N4/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24/h2-13H,14-17H2,1H3,(H,25,26)
InChIKey
QZKGUNQLVFEEBA-UHFFFAOYSA-N
PubChem Compound ID
540335
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Inhibitor [528472]
Alpha-2C adrenergic receptor Target Info Inhibitor [528472]
Alpha-2A adrenergic receptor Target Info Inhibitor [528472]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signaling
References
Ref 528472J Med Chem. 2006 Oct 19;49(21):6351-63.Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists.
Ref 528472J Med Chem. 2006 Oct 19;49(21):6351-63.Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists.

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