TTD | Drug: D05GMW

Drug General Information
Drug ID	D05GMW
Former ID	DNC006232
Drug Name	4-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527871]
Structure		Download 2D MOL 3D MOL
Formula	C15H10N2O2
Canonical SMILES	CC1=CC2=C(C3=CC=CC=C3N2)C4=C1C(=O)NC4=O
InChI	1S/C15H10N2O2/c1-7-6-10-12(8-4-2-3-5-9(8)16-10)13-11(7)14(18)17-15(13)19/h2-6,16H,1H3,(H,17,18,19)
InChIKey	DSCSSQAANWCYAP-UHFFFAOYSA-N
PubChem Compound ID	44407566
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[527871]
KEGG Pathway	Base excision repair
KEGG Pathway	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 527871	Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.
Ref 527871	Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. Epub 2005 Nov 15.Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors.

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Drug Information