Drug Information

Drug General Information
Drug ID
D05IPO
Former ID
DCL000732
Drug Name
BTS-79018
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Terminated [536463]
Company
Abbott
Structure
Download
2D MOL

3D MOL
Formula
C22H27ClN2O3
Canonical SMILES
COC1=CC=CC=C1N2CCC(CC2)CNCC3COC4=C(O3)C=C(C=C4)Cl
InChI
1S/C22H27ClN2O3/c1-26-20-5-3-2-4-19(20)25-10-8-16(9-11-25)13-24-14-18-15-27-21-7-6-17(23)12-22(21)28-18/h2-7,12,16,18,24H,8-11,13-15H2,1H3
InChIKey
QHLRKDSRGUZHSH-UHFFFAOYSA-N
CAS Number
CAS 170353-17-0
PubChem Compound ID
9865858
PubChem Substance ID
14830639, 45288124, 78814439, 85224654, 103337393, 103972053, 129023584, 134339228, 232456816
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Binder [536463]
5-hydroxytryptamine 1A receptor Target Info Binder [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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