Drug Information

Drug General Information
Drug ID
D05KQE
Former ID
DIB003608
Drug Name
MK-287
Synonyms
L-680573; (-)-(S,S)-2-[3-(2-Hydroxyethylsulfonyl)-5-methoxy-4-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 2 [544956]
Structure
Download
2D MOL

3D MOL
Formula
C25H34O9S
Canonical SMILES
CCCOc1c(OC)cc(cc1S(=O)(=O)CCO)[C@@H]2CC[C@H](O2)c3cc(OC<br />)c(OC)c(OC)c3
InChI
1S/C25H34O9S/c1-6-10-33-25-22(31-4)14-17(15-23(25)35(27,28)11-9-26)19-8-7-18(34-19)16-12-20(29-2)24(32-5)21(13-16)30-3/h12-15,18-19,26H,6-11H2,1-5H3/t18-,19-/m0/s1
InChIKey
WXIDMVGKJBAEFP-OALUTQOASA-N
CAS Number
CAS 135947-75-0
PubChem Compound ID
131925
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [531635], [534027]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544956Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001713)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 534027MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor. J Lipid Mediat. 1993 Jun;7(2):115-34.

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