Drug Information

Drug General Information
Drug ID
D05NBK
Former ID
DNC012367
Drug Name
1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529371]
Structure
Download
2D MOL

3D MOL
Formula
C16H23NO3
Canonical SMILES
C1CCC(CC1)C2CC3=C(C=CC(=C3O)O)C(O2)CN
InChI
1S/C16H23NO3/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10/h6-7,10,14-15,18-19H,1-5,8-9,17H2/t14-,15-/m0/s1
InChIKey
BOKASTZDGGZFET-GJZGRUSLSA-N
PubChem Compound ID
15696466
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [529371]
D(2) dopamine receptor Target Info Inhibitor [529371]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04015:Rap1 signaling pathway
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 529371J Med Chem. 1991 Oct;34(10):2946-53.Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.
Ref 529371J Med Chem. 1991 Oct;34(10):2946-53.Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.

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