Drug General Information
Drug ID
D05ORO
Former ID
DIB002359
Drug Name
Anti-N3pG-Abeta antibody
Drug Type
Antibody
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1 [524268]
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info [550236]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 524268ClinicalTrials.gov (NCT01837641) A Study of LY3002813 in Participants With Alzheimer's Disease. U.S. National Institutes of Health.
Ref 550236LY3002813 Alzheimer's Disease (Phase 1). Eli Lilly & Co.

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