Drug General Information
Drug ID
D05PZV
Former ID
DNC009412
Drug Name
4-(2,2'-bithiophen-5-ylmethyleneamino)phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529388]
Structure
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2D MOL

3D MOL

Formula
C15H11NOS2
Canonical SMILES
C1=CSC(=C1)C2=CC=C(S2)C=NC3=CC=C(C=C3)O
InChI
1S/C15H11NOS2/c17-12-5-3-11(4-6-12)16-10-13-7-8-15(19-13)14-2-1-9-18-14/h1-10,17H
InChIKey
UMPJRGAFFRSXRX-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Collagenase 3 Target Info Inhibitor [529388]
NetPath Pathway IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix Metalloproteinases
References
Ref 529388Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. Epub 2008 Mar 6.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Ref 529388Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. Epub 2008 Mar 6.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.

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