Drug General Information
Drug ID	D05QDO
Former ID	DNC003658
Drug Name	2-amidino-4-iodobenzothiophene
Synonyms	4-Iodo-benzo[b]thiophene-2-carboxamidine
Indication	Discovery agent		Investigative	[530682]
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1=CC2=C(C=C(S2)C(=N)N)C(=C1)I
InChI	1S/C9H7IN2S/c10-6-2-1-3-7-5(6)4-8(13-7)9(11)12/h1-4H,(H3,11,12)
InChIKey	YERQOXAYAFWFEJ-UHFFFAOYSA-N
Target and Pathway
Target(s)	Coagulation factor IX	Target Info	Inhibitor	[530682]
	Urokinase-type plasminogen activator	Target Info	Inhibitor	[526259]
KEGG Pathway	Complement and coagulation cascadeshsa04064:NF-kappa B signaling pathway
	Complement and coagulation cascades
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Blood coagulationP00011:Blood coagulation
	Plasminogen activating cascade
	CCKR signaling map ST
Pathway Interaction Database	Beta1 integrin cell surface interactions
	E2F transcription factor network
	Beta3 integrin cell surface interactions
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	amb2 Integrin signaling
	ATF-2 transcription factor network
	AP-1 transcription factor network
	Beta2 integrin cell surface interactions
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	FGF signaling pathway
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-75205:Dissolution of Fibrin Clot
WikiPathways	Complement and Coagulation Cascades
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)WP710:DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Endochondral Ossification
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Dissolution of Fibrin Clot
	Osteopontin Signaling
References
Ref 530682	J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Ref 526259	Bioorg Med Chem Lett. 2002 Feb 11;12(3):491-5.Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
Ref 530682	J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.

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