TTD | Drug: D05RRZ

Drug General Information
Drug ID	D05RRZ
Former ID	DIB019907
Drug Name	Glaxo-11p
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543232]
Structure		Download 2D MOL
Formula	C35H36N6O4
InChI	InChI=1S/C35H36N6O4/c1-24(2)40(28-21-19-26(20-22-28)38(3)4)31(42)23-39-29-17-11-12-18-30(29)41(27-15-9-6-10-16-27)34(44)32(33(39)43)37-35(45)36-25-13-7-5-8-14-25/h5-22,24,32H,23H2,1-4H3,(H2,36,37,45)
InChIKey	GESRVUYUMYPJBC-UHFFFAOYSA-N
PubChem Compound ID	10348659
PubChem Substance ID	15360144, 22711409, 33981706, 78120149, 135650305, 164151028, 242096270
Target and Pathway
Target(s)	Cholecystokinin receptor type A	Target Info	Agonist	[534086]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Insulin secretion
	Pancreatic secretion
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543232	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 866).
Ref 534086	Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger". J Med Chem. 1996 Jan 19;39(2):562-9.

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Drug Information