Drug General Information
Drug ID	D05SSJ
Former ID	DIB012094
Drug Name	Dotarizine
Synonyms	Dotarazine; FI-6020; FI-6026
Drug Type	Small molecular drug
Indication	Migraine [ICD9: 346; ICD10:G43]		Terminated	[525748]
Company	Ferrer Internacional SA
Structure		Download 2D MOL 3D MOL
Formula	C29H34N2O2
Canonical SMILES	C1(OCCO1)(c1ccccc1)CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1
CAS Number	CAS 84625-59-2
PubChem Compound ID	55285
Target and Pathway
Target(s)	5-HT 2 receptor	Target Info	Modulator	[525748]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
References
Ref 525748	Vasostabilizing effect of Dotarizine (Ca(2+)-channel blocker) on cerebrovascular reactivity in rabbits. Neurol Res. 2000 Mar;22(2):229-32.
Ref 525748	Vasostabilizing effect of Dotarizine (Ca(2+)-channel blocker) on cerebrovascular reactivity in rabbits. Neurol Res. 2000 Mar;22(2):229-32.

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