Drug Information

Drug General Information
Drug ID
D05TAD
Former ID
DNC001061
Drug Name
ONO-6818
Drug Type
Small molecular drug
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [547077]
Structure
Download
2D MOL

3D MOL
Formula
C23H30N6O4
Canonical SMILES
CC(C)C(C(C1=NN=C(O1)C(C)(C)C)O)NC(=O)CN2C(=NC=C(C2=O)N)<br />C3=CC=CC=C3
InChI
1S/C23H30N6O4/c1-13(2)17(18(31)20-27-28-22(33-20)23(3,4)5)26-16(30)12-29-19(14-9-7-6-8-10-14)25-11-15(24)21(29)32/h6-11,13,17-18,31H,12,24H2,1-5H3,(H,26,30)/t17-,18-/m0/s1
InChIKey
HMPQTEPEMQZWQH-ROUUACIJSA-N
CAS Number
CAS 16096-98-3
PubChem Compound ID
5287543
PubChem Substance ID
7885453, 39320152, 53790702, 75631821, 113869916, 134340033, 134340312, 239996558
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [535494]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 547077Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012873)
Ref 535494Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.