Drug General Information
Drug ID	D05VVC
Former ID	DNC012434
Drug Name	7-chloro-3-hydroxyquinazoline-2,4-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528453]
Structure		Download 2D MOL 3D MOL
Formula	C8H5ClN2O3
Canonical SMILES	C1=CC2=C(C=C1Cl)NC(=O)N(C2=O)O
InChI	1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)
InChIKey	CRTPJJNXJPKDEZ-UHFFFAOYSA-N
PubChem Compound ID	44315786
Target and Pathway
Target(s)	Glutamate receptor 1	Target Info	Inhibitor	[528453]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[528453]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[528453]
	Glutamate receptor AMPA subtype	Target Info	Inhibitor	[528453]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[528453]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Dopaminergic synapse
	Long-term depression
	Amyotrophic lateral sclerosis (ALS)
	Amphetamine addiction
	Nicotine addictionhsa04014:Ras signaling pathway
	Rap1 signaling pathway
	Alzheimer's disease
	Huntington's disease
	Cocaine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Calcium signaling pathway
PANTHER Pathway	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathwayP00029:Huntington disease
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	EPHB forward signalingerbb4_pathway:ErbB4 signaling events
	Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome	COPII (Coat Protein 2) Mediated Vesicle Transport
	Trafficking of AMPA receptors
	Trafficking of GluR2-containing AMPA receptors
	Unblocking of NMDA receptor, glutamate binding and activation
	Cargo concentration in the ERR-HSA-3928662:EPHB-mediated forward signaling
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Amyotrophic lateral sclerosis (ALS)
	BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
	Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 528453	J Med Chem. 2006 Oct 5;49(20):6015-26.Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Ref 528453	J Med Chem. 2006 Oct 5;49(20):6015-26.Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.

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