Drug Information

Drug General Information
Drug ID
D05WQR
Former ID
DNC003577
Drug Name
3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol
Synonyms
HTR5A3-(2-Amino-ethyl)-2-methyl-1H-indol-5-ol
Indication Discovery agent Investigative [532034]
Structure
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2D MOL

3D MOL
Canonical SMILES
CC1=C(C2=C(N1)C=CC(=C2)O)CCN
InChI
1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
InChIKey
WYWNEDARFVJQSG-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [526655]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [532034]
5-hydroxy-tryptamine 3B receptor Target Info Inhibitor [532034]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04375:5HT3 type receptor mediated signaling pathwayP04375:5HT3 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-975298:Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Iron uptake and transportWP2670:Iron uptake and transport
References
Ref 532034J Med Chem. 1990 Jan;33(1):13-6.Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.
Ref 526655J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Ref 532034J Med Chem. 1990 Jan;33(1):13-6.Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.

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