Drug Information

Drug General Information
Drug ID
D05YUK
Former ID
DIB009788
Drug Name
FOROPAFANT
Synonyms
SR-27417; Foropafant < Prop INN >; 2-[N-[2-(Dimethylamino)ethyl]-N-(3-pyridylmethyl)amino]-4-(2,4,6-triisopropylphenyl)thiazole
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 3 [539165], [545088]
Structure
Download
2D MOL

3D MOL
Formula
C28H40N4S
InChI
InChI=1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3
InChIKey
VVBFISAUNSXQGZ-UHFFFAOYSA-N
CAS Number
CAS 136468-36-5
PubChem Compound ID
119368
PubChem Substance ID
7980658, 10238464, 12014626, 14931747, 29300264, 52627176, 57339460, 85209765, 99222795, 104408164, 124958916, 126434302, 126591593, 129531257, 135075012, 135651077, 160838918, 162159535, 163099178, 163403181, 163846298, 163906038, 164779918, 170558734, 179149864, 184526978, 184547726, 198979497, 202819982, 204364912, 223536043, 223704937, 232805676, 252215439, 252268280, 252496134
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [525756], [528090], [531635]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539165(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1856).
Ref 545088Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002078)
Ref 525756In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. Vet Res. 2000 Mar-Apr;31(2):267-72.
Ref 528090Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51.
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.

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