Drug General Information
Drug ID	D06BUA
Former ID	DIB002912
Drug Name	Nexopamil
Synonyms	LU-49938
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Phase 2	[533605]
Company	BASF AG
Structure		Download 2D MOL 3D MOL
Formula	C24H40N2O3
Canonical SMILES	c1([C@@](C#N)(C(C)C)CCCN(CCCCCC)C)cc(c(c(c1)OC)OC)OC
PubChem Compound ID	65984
Target and Pathway
Target(s)	Calcium channel	Target Info	Blocker	[533605]
	5-HT 2 receptor	Target Info	Modulator	[533605]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
References
Ref 533605	Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.
Ref 533605	Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.

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