Drug Information

Drug General Information
Drug ID
D06DIH
Former ID
DNC003110
Drug Name
Furo[2,3d]Pyrimidine Antifolate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
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2D MOL

3D MOL
Formula
C20H22N6O6
Canonical SMILES
CN(CC1=COC2=NC(=NC(=C12)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O<br />)O)C(=O)O
InChI
1S/C20H22N6O6/c1-26(8-11-9-32-18-15(11)16(21)24-20(22)25-18)12-4-2-10(3-5-12)17(29)23-13(19(30)31)6-7-14(27)28/h2-5,9,13H,6-8H2,1H3,(H,23,29)(H,27,28)(H,30,31)(H4,21,22,24,25)/t13-/m0/s1
InChIKey
WXINNGCGSCFUCR-ZDUSSCGKSA-N
PubChem Compound ID
158376
PubChem Substance ID
636882, 7886708, 7889003, 10253320, 15453177, 26704347, 26706675, 26706677, 26706679, 46233824, 57348491, 80058309, 103326331, 103989529, 113439782, 135256194, 162797442
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [551393]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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