Drug Information

Drug General Information
Drug ID
D06EEE
Former ID
DNCL003335
Drug Name
YM060
Synonyms
Ramosetron
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Phase 4 [523218]
Company
Astellas
Structure
Download
2D MOL

3D MOL
Formula
C17H17N3O
Canonical SMILES
CN1C=C(C2=CC=CC=C21)C(=O)C3CCC4=C(C3)NC=N4
InChI
1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1
InChIKey
NTHPAPBPFQJABD-LLVKDONJSA-N
CAS Number
CAS 132907-72-3
PubChem Compound ID
108000
PubChem Substance ID
14824418, 14848693, 44436913, 49830772, 50070718, 50112691, 71879502, 79053930, 96025152, 104380246, 124974479, 125084556, 128751655, 131297527, 135141836, 135650885, 137446772, 140430812, 152035422, 172659137, 179149824, 184546127, 198983023, 223562331, 224977577, 226406853, 241031501, 251912291, 251916599
Target and Pathway
Target(s) 5-Hydroxytryptamine 3 receptor Target Info Modulator [533601]
References
Ref 523218ClinicalTrials.gov (NCT01225237) A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients. U.S. National Institutes of Health.
Ref 533601Inhibitory effect of YM060 on 5-HT3 receptor-mediated depolarization in colonic myenteric neurons of the guinea pig. Eur J Pharmacol. 1995 Sep 5;283(1-3):107-12.

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