Drug General Information
Drug ID
Former ID
Drug Name
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [548874]
Chugai; Roche
Target and Pathway
Target(s) mRNA of B-Raf Target Info Inhibitor [551608]
mRNA of A-Raf Target Info Inhibitor [551608]
MEK protein kinase Target Info Inhibitor [551608]
mRNA of RAF proto-oncogene serine/threonine-protein kinase Target Info Modulator [551608]
Dual specificity mitogen-activated protein kinase kinase Target Info Modulator [551608]
MAP Target Info Modulator [551608]
BioCyc Pathway MAP kinase cascade
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
mTOR signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Natural killer cell mediated cytotoxicity
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Prostate cancer
Thyroid cancer
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancerhsa04012:ErbB signaling pathway
Non-small cell lung cancerhsa04010:MAPK signaling pathway
Ras signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Cholinergic synapse
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Hepatitis B
Influenza A
MicroRNAs in cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Choline metabolism in cancer
NetPath Pathway IL-7 Signaling PathwayNetPath_17:IL5 Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Angiogenesis
Integrin signalling pathway
Interleukin signaling pathway
PDGF signaling pathway
T cell activation
VEGF signaling pathway
Ras Pathway
CCKR signaling map STP00005:Angiogenesis
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map ST
Pathway Interaction Database CDC42 signaling events
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
ErbB1 downstream signaling
PDGFR-beta signaling pathway
Signaling events mediated by VEGFR1 and VEGFR2
Trk receptor signaling mediated by the MAPK pathwayfcer1pathway:Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
SHP2 signaling
IL2-mediated signaling events
IGF1 pathway
Ceramide signaling pathway
ErbB2/ErbB3 signaling events
p38 signaling mediated by MAPKAP kinases
Nongenotropic Androgen signaling
Internalization of ErbB1
CXCR3-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
Class I PI3K signaling events mediated by Akt
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Insulin SignallingPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Insulin Signalling
Reactome Spry regulation of FGF signaling
Frs2-mediated activation
ARMS-mediated activation
CREB phosphorylation through the activation of Ras
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathwayR-HSA-5673000:RAF activation
Negative regulation of MAPK pathwayR-HSA-110056:MAPK3 (ERK1) activation
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activationR-HSA-2672351:Stimuli-sensing channels
GP1b-IX-V activation signalling
CD209 (DC-SIGN) signaling
Negative regulation of MAPK pathway
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin HTR1 Group and FOS Pathway
Senescence and Autophagy in Cancer
Regulation of Actin Cytoskeleton
EGF/EGFR Signaling Pathway
MAPK Cascade
MAPK Signaling Pathway
Bladder Cancer
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Polycystic Kidney Disease Pathway
Corticotropin-releasing hormone
B Cell Receptor Signaling Pathway
Signaling Pathways in Glioblastoma
Integrated Breast Cancer Pathway
Signaling by FGFR
NGF signalling via TRKA from the plasma membrane
Integrin-mediated Cell AdhesionWP673:ErbB Signaling Pathway
Integrin-mediated Cell AdhesionWP75:Toll-like receptor signaling pathway
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
TCR Signaling Pathway
ErbB Signaling Pathway
Hypothetical Network for Drug Addiction
EPO Receptor Signaling
IL-2 Signaling Pathway
Insulin Signaling
TGF beta Signaling Pathway
IL-6 signaling pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
IL-3 Signaling Pathway
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
RAF/MAP kinase cascade
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
Nifedipine Activity
PDGF Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
Prostate Cancer
TSLP Signaling Pathway
IL-9 Signaling Pathway
Endothelin Pathways
IL-7 Signaling Pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
Integrin-mediated Cell Adhesion
L1CAM interactions
MicroRNAs in cardiomyocyte hypertrophy
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling PathwayWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Extracellular vesicle-mediated signaling in recipient cells
Iron uptake and transport
Retinoblastoma (RB) in Cancer
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
FSH signaling pathway
Rap1 signalling
GP1b-IX-V activation signalling
IL-5 Signaling Pathway
Ref 548874Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029782)
Ref 551608Clinical pipeline report, company report or official report of Roche.

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