TTD | Drug: D06EGM

Drug General Information
Drug ID	D06EGM
Former ID	DIB020664
Drug Name	PD-307243
Synonyms	PD307243; PD 307243
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542656]
Structure		Download 2D MOL
Formula	C20H15Cl2N3O2
InChI	InChI=1S/C20H15Cl2N3O2/c21-17-6-5-15(9-18(17)22)25-10-12-3-4-14(8-13(12)11-25)24-19-16(20(26)27)2-1-7-23-19/h1-9H,10-11H2,(H,23,24)(H,26,27)
InChIKey	WNXIPCSWXVTKQF-UHFFFAOYSA-N
PubChem Compound ID	54440733
PubChem Substance ID	129608703, 134222983, 137212824, 223366012, 232289385
Target and Pathway
Target(s)	Potassium voltage-gated channel subfamily H member 2	Target Info	Activator	[529181]
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Voltage gated Potassium channels
WikiPathways	SIDS Susceptibility Pathways
	Hematopoietic Stem Cell Differentiation
	Potassium Channels
References
Ref 542656	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7677).
Ref 529181	2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels. Mol Pharmacol. 2008 Mar;73(3):639-51. Epub 2007 Nov 27.

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Drug Information