Drug Information

Drug General Information
Drug ID
D06EWO
Former ID
DAP000390
Drug Name
Gemtuzumab ozogamicin
Synonyms
Mylotarg (TN)
Drug Type
Antibody
Indication Acute myeloid leukemia [ICD9: 205; ICD10:C92.0] Approved [536361], [541855]
Therapeutic Class
Anticancer Agents
Company
Wyeth Pharmaceuticals
CAS Number
CAS 220578-59-6
SuperDrug ATC ID
L01XC05
Target and Pathway
Target(s) Myeloid cell surface antigen CD33 Target Info [535660], [537216], [537245], [537367], [537432]
KEGG Pathway Hematopoietic cell lineage
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541855(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6775).
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 537216Phase I/II study of humanized anti-CD33 antibody conjugated with calicheamicin, gemtuzumab ozogamicin, in relapsed or refractory acute myeloid leukemia: final results of Japanese multicenter cooperative study. Int J Hematol. 2009 May;89(4):460-9. Epub 2009 Apr 10.
Ref 537245Successful treatment with gemtuzumab ozogamicin monotherapy in a pediatric patient with resistant relapse of acute myeloid leukemia. Turk J Pediatr. 2009 Jan-Feb;51(1):69-71.
Ref 537367Deficient activation of Bak and Bax confers resistance to gemtuzumab ozogamicin-induced apoptotic cell death in AML. Exp Hematol. 2009 Jun;37(6):755-66.
Ref 537432Targeted treatment of acute myeloid leukemia in older adults: role of gemtuzumab ozogamicin. Clin Interv Aging. 2009;4(1):197-205. Epub 2009 May 14.

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