Drug Information

Drug General Information
Drug ID
D06FPQ
Former ID
DAP000063
Drug Name
Frovatriptan
Synonyms
Allegro; Auradol; Frova; Frovelan; Migard; Miguard; Rilamig; Allergo filmtabletten; SB 209509; Allergo filmtabletten(TN); Frova (TN); Frovatriptan (INN); SB-209509; (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide; (6R)-6-(methylamino)-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide; (R)-5,6,7,8-Tetrahydro-6-(methylamino)carbazole-3-carboxamide
Drug Type
Small molecular drug
Indication Migraine headaches [ICD9: 346; ICD10:G43] Approved [536361], [542203]
Therapeutic Class
Antimigraine Agents
Company
Vernalis
Structure
Download
2D MOL

3D MOL
Formula
C14H17N3O
InChI
InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1
InChIKey
XPSQPHWEGNHMSK-SECBINFHSA-N
CAS Number
CAS 158747-02-5
PubChem Compound ID
77992
PubChem Substance ID
7979332, 8199305, 12014901, 14749650, 15221001, 43133577, 46506288, 48416039, 50070536, 50071300, 50288893, 57332463, 93167160, 96024690, 103396317, 103967002, 104368726, 126658118, 126667006, 129723338, 134223840, 134337391, 135035469, 137002444, 138365609, 160964334, 175265638, 178103766, 179150020, 184527647, 223660569, 226420875
SuperDrug ATC ID
N02CC07
SuperDrug CAS ID
cas=158747025
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator [556264]
5-hydroxytryptamine 1D receptor Target Info Modulator [556264]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542203(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7191).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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