Drug Information

Drug General Information
Drug ID
D06FZX
Former ID
DAP001347
Drug Name
Antazoline
Synonyms
Analergine; Antastan; Antasten; Antazolin; Antazolina; Antazolinum; Antihistal; Antistin; Antistine; Azalone; Histostab;Imidamin; Imidamine; Phenazolin; Phenazoline; Antazolina [Spanish]; Antazolinum [Latin]; Antazolina [INN-Spanish]; Antazoline (INN); Antazoline [INN:BAN]; Antazolinum [INN-Latin]; Ben-A-hist; N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline; 2-(N-Benzylanilinomethyl)-2-imidazoline; 2-(N-Phenyl-N-benzylaminomethyl)imidazoline; 2-Phenyl-benzyl-amino-methylimidazolin; 2-Phenyl-benzyl-amino-methylimidazolin [German]; 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine; 5512-M
Drug Type
Small molecular drug
Indication Nasal congestion [ICD9: 478.19; ICD10:J34.89] Approved [538515], [542123]
Structure
Download
2D MOL

3D MOL
Formula
C17H19N3
InChI
InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
InChIKey
REYFJDPCWQRWAA-UHFFFAOYSA-N
CAS Number
CAS 91-75-8
PubChem Compound ID
2200
PubChem Substance ID
5141625, 7978713, 8151493, 10537839, 11112519, 11113348, 11335258, 11360497, 11363683, 11366245, 11368807, 11371466, 11373721, 11376969, 11461469, 11466286, 11467406, 11484934, 11486031, 11489075, 11490119, 11491956, 11494603, 15070645, 29221378, 47365022, 47440086, 47440087, 47810597, 47885255, 47885256, 48259060, 48415573, 49698409, 49980605, 50100471, 50100472, 50265613, 51091789, 56366164, 57321196, 85083863, 85209552, 85788777, 85789405, 99445269, 103404110, 104299901, 118269282, 123120968
SuperDrug ATC ID
R01AC04; R06AX05
SuperDrug CAS ID
cas=000091758
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [534867], [535973], [537070], [537691]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538515FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018746.
Ref 542123(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7116).
Ref 534867A current appreciation of sites for pharmacological intervention in allergic conjunctivitis: effects of new topical ocular drugs. Acta Ophthalmol Scand Suppl. 1999;(228):33-7.
Ref 535973Influence of antazoline and ketotifen on the anticonvulsant activity of conventional antiepileptics against maximal electroshock in mice. Eur Neuropsychopharmacol. 2004 Aug;14(4):307-18.
Ref 537070Histamine and the convulsive threshold or effectiveness of antiepileptic drugs. Przegl Lek. 2008;65(11):803-6.
Ref 537691Nonsedating histamine H1-receptor antagonists. Clin Pharm. 1989 May;8(5):331-44.

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