Drug Information

Drug General Information
Drug ID
D06GGB
Former ID
DNC014092
Drug Name
N-Ethyl-2-phenylnorapomorphine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530150]
Structure
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2D MOL

3D MOL
Formula
C24H24ClNO2
Canonical SMILES
CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl
InChI
1S/C24H23NO2.ClH/c1-2-25-11-10-17-12-18(15-6-4-3-5-7-15)13-19-22(17)20(25)14-16-8-9-21(26)24(27)23(16)19;/h3-9,12-13,20,26-27H,2,10-11,14H2,1H3;1H/t20-;/m1./s1
InChIKey
PVSIQQPPTJUREU-VEIFNGETSA-N
PubChem Compound ID
45271621
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [530150]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 530150Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. Epub 2009 May 3.N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.
Ref 530150Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. Epub 2009 May 3.N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.

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