TTD | Drug: D06GIL

Drug General Information
Drug ID	D06GIL
Former ID	DIB020103
Drug Name	JMV3008
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541181]
Structure		Download 2D MOL
Formula	C35H37N7O3
InChI	InChI=1S/C35H37N7O3/c1-4-22-21-41(30-14-8-6-11-26(22)30)35-40-39-33(42(35)31-16-15-24(44-2)19-32(31)45-3)29(38-34(43)28-13-9-17-36-28)18-23-20-37-27-12-7-5-10-25(23)27/h5-8,10-12,14-16,19-21,28-29,36-37H,4,9,13,17-18H2,1-3H3,(H,38,43)/t28-,29+/m0/s1
InChIKey	YAWJYESYIAWFJX-URLMMPGGSA-N
PubChem Compound ID	74015851
PubChem Substance ID	178102496
Target and Pathway
Target(s)	Growth hormone secretagogue receptor type 1	Target Info	Antagonist	[529089]
KEGG Pathway	cAMP signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	Leptin Signaling Pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541181	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5872).
Ref 529089	Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem. 2007 Nov 15;50(23):5790-806. Epub 2007 Oct 10.

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Drug Information